ea0044p124 | Neoplasia, cancer and late effects | SFEBES2016
Gorvin Caroline
, Newey Paul
, Stokes Victoria
, Rogers Angela
, Ntali Georgia
, Lees Peter
, Karavitaki Niki
, Grossman Ashley
, Thakker Rajesh
The prolactin receptor (PRLR) is a type-I cytokine receptor that plays critical roles in mammary gland development, lactation and glucose metabolism, and PRLR mutations have been associated with breast cancer and familial hyperprolactinaemia. The PRLR signals via Janus kinase-2-signal transducer and activator of transcription-5 (JAK2-STAT5) or phosphoinositide 3-kinase-Akt (PI3K-Akt) pathways to mediate changes in transcription, differentiation and proliferation, and we hypoth...